Mood Disorders - All Natural Advantage

 

Genetic Susceptibilities

Our genetic makeup and hence individual biochemistry plays a major role in determining the factors that will affect each of us and how these impact on our mental health. Certain people may have a disposition to deficiencies in certain nutrients and hormones which can lead to an imbalance of neurotransmitters and the development of mood / mental disorders. Neurotransmitter imbalances can be genetic in nature and involve abnormal absorption, metabolism and / or storage of key nutrients. Our individual biochemistry can help to determine which nutrients are individually required to balance health and prevent more serious disorders.

 

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Pyroluria

This genetic condition is related to an error in pyrole chemistry. These people have a chemical called kryptopyrrole detectable in their urine, which binds with vitamin B6 and zinc, depleting the body of these nutrients. Symptoms associated with pyroluria: explosive temper, mood swings, poor short-term memory, frequent infections, fearfulness, continuous stress and anxiety.

 

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Low Magnesium

A high proportion of the population is deficient in this vital mineral, magnesium. Magnesium has a calming effect on the body and is required for many of the body’s metabolic processes. Common symptoms associated with magnesium deficiency include: an exaggerated startle response, anxiety, palpitations, ramping, irregular heartbeat, premenstrual syndrome.

 

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Elevated Stress Hormones

Chronic stress can lead to excessive stress hormone levels circulating within the body and the normal regulating mechanisms may no longer be able to cope. Chronic stress depletes the body of many vital nutrients. The body cannot begin to cope with chronic stress without these vital nutrients. Some signs of nutrient depletion include an inability to cope with stress, fatigue, depression and impaired immunity.

Nutrients which can be invaluable for helping the body cope with stress include: magnesium, vitamin B5, vitamin C, tyrosine, tryptophan, acety-l-carnitine and phosphatidylserine.

 

RECOMMENDED TESTS:

Gastrointestinal Issues

Any digestive disorder will affect the absorption of nutrients. Abnormally low or high hydrochloric acid, pancreatic enzyme deficiency, a “leaky gut” and inflammatory bowel disease (such as irritable bowel syndrome or gluten sensitivity) can contribute to deficiencies in certain nutrients and promote food sensitivities. This can lead to protein (amino acid) deficiency and directly affect the production of neurotransmitters that affect mood. If the integrity of the gut lining is damaged toxic substances may also be passed through into the bloodstream affecting mental health.

 

RECOMMENDED TESTS:

Hormone Imbalance

Research has discovered that anxiety disorders are associated with abnormal levels of certain hormones. People with anxiety tend to have higher than usual levels of a hormone called, corticotropin releasing factor (CRF), which switches on the stress response by initiating cortisol production (the main stress hormone). Other hormone secreting glands are also stimulated resulting in the dominance of certain hormones and inducing deficiencies in others. Low thyroid hormones are associated with depression and anxiety. An imbalance of the oestrogen to progesterone ratio can contribute to decreased blood sugar control, impaired immunity, migraines, mood swings, depression and violent outbursts. Low testosterone is associated with lack of interest and passive behaviour, whereas elevated levels are associated with aggression.

 

RECOMMENDED TESTS:

  • Comprehensive thyroid function testing
  • Organic Acid Test, Female/ Male Hormonal Testing

Nutrient Deficiencies

Individuals suffering from mood disorders may be deficient in particular nutrients and must be supported with appropriate nutritional supplementation.

 

RECOMMENDED TESTS:

Nutrients of particular importance:

  • Vitamin B12, vitamin B6 and folate: low levels are associated with mood disorders
  • B complex vitamins, magnesium, zinc, iron, copper, vitamin C, etc are all essential cofactors involved in maintaining a good balance of neurotransmitters involved in mood and behaviour
  • Omega-3 fatty acids (DHA): DHA is essential to healthy brain functioning and inadequate levels may contribute to depression, poor concentration and memory
  • Specific amino acids essential for neurotransmitter health include tyrosine, phenylalanine, tryptophan, histamine and glutamine.

 

Herbal Medicine in Mood Disorders

Herbal medicine has a long tradition in treating mood disorders successfully, without the unwanted side effects of prescription medications.

  • Hypericum perforatum is famous for its application for nervous tension and has a reputation as restorative for depression and anxiety
  • Ziziphus jujuba has been used widely in Traditional Chinese Medicine for the treatment of insomnia and anxiety
  • Piper methysticum is used in conditions associated with anxiety especially when associated with depression, nervousness and stress
  • Scutellaria laterifolia helps rebalance the adrenal (stress) hormones and is therefore useful during nervous exhaustion and depression.

 

Mood Disorders, Diet, Nutrient Deficiencies and Gut Health – What is the Connection?

Mood Disorders and Diet

 

Dietary patterns and depression risk: A meta-analysis.A dietary pattern characterized by a high intakes of fruit, vegetables, whole grain, fish, olive oil, low-fat dairy and antioxidants and low intakes of animal foods was apparently associated with a decreased risk of depression. A dietary pattern characterized by a high consumption of red and/or processed meat, refined grains, sweets, high-fat dairy products, butter, potatoes and high-fat gravy, and low intakes of fruits and vegetables is associated with an increased risk of depression. The results of this meta-analysis suggest that healthy pattern may decrease the risk of depression, whereas western-style may increase the risk of depression.”

Food and Mood: Diet Quality is Inversely Associated with Depressive Symptoms in Female University Students.Researchers have found support for an inverse association between diet quality and depressive symptoms in middle-aged adults. This association has not been well examined among university students, a population at risk of developing both depression and unhealthy lifestyle habits. Elevated depressive symptoms were associated with consumption of diets of poor nutritional quality in our female university student sample. Thus, healthy eating may correspond with lower levels of depression in young adult females.”

Fruit and vegetable consumption and psychological distress: cross-sectional and longitudinal analyses based on a large Australian sample. Full pdf. “Growing evidence suggests a link between diet and mental health. Increasing fruit and vegetable consumption may help reduce psychological distress in middle-aged and older adults.”

Effects of Acute Blueberry Flavonoids on Mood in Children and Young Adults. Full pdf. “These randomised, placebo-controlled, double-blind studies investigated the effects of acute consumption of a flavonoid-rich wild blueberry drink on the mood of healthy children and young adults. In both studies, increased Positive Affect was observed 2 h after consumption of the flavonoid-rich WBB drink (significant drink by session interaction). The flavonoid drink had no effect on Negative Affect. The effect of flavonoids on mood was consistent across two populations, at two different time points (morning and afternoon), and in a between- and within-subject design. Thus, the positive effect of blueberry flavonoids on Positive Affect appears to be robust to variations in experimental design.”

Association between depression and fruit and vegetable consumption among adults in South Asia. Full pdf. “Daily intake of less than five servings of F&V [fruit and vegetables] was associated with higher odds of depression. Nutrition programs aimed at promoting F&V consumption might prove beneficial to reduce the prevalence of depression in south Asian population. Further studies are required to understand the factors limiting the adequate consumption of F&V.”

Bread and Other Edible Agents of Mental Disease. Full pdf. “Perhaps because gastroenterology, immunology, toxicology, and the nutrition and agricultural sciences are outside of their competence and responsibility, psychologists and psychiatrists typically fail to appreciate the impact that food can have on their patients’ condition. We present the implications for the psychological sciences of the findings that, in all of us, bread (1) makes the gut more permeable and can thus encourage the migration of food particles to sites where they are not expected, prompting the immune system to attack both these particles and brain-relevant substances that resemble them, and (2) releases opioid-like compounds, capable of causing mental derangement if they make it to the brain.”

 

Mood Disorders and Gut Health

 

The effects of probiotics on depressive symptoms in humans: a systematic review.In the last decade, research has revealed an extensive bidirectional communication network between the gastrointestinal tract and the central nervous system, referred to as the “gut-brain axis.” Advances in this field have linked psychiatric disorders to changes in the microbiome, making it a potential target for novel antidepressant treatments. Ten studies met criteria and were analyzed for effects on mood, anxiety, and cognition. Five studies assessed mood symptoms, seven studies assessed anxiety symptoms, and three studies assessed cognition. The majority of the studies found positive results on all measures of depressive symptoms.”

The Gut-Brain Axis: The Missing Link in Depression. Full pdf. “In the past few years, neuroscientific research has shown the importance of the microbiota in the development of brain systems. Recent studies showed that the microbiota could activate the immune and central nervous systems, including commensal and pathogenic microorganisms in the gastrointestinal tract. Gut microorganisms are capable of producing and delivering neuroactive substances such as serotonin and gamma-aminobutyric acid, which act on the gut-brain axis.”

Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities.Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut-brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM). Intestinal dysbiosis and the leaky gut may constitute a key pathophysiological link between MDD and its medical comorbidities.”

Probiotics and Subclinical Psychological Symptoms in Healthy Participants: A Systematic Review and Meta-Analysis.These results show that probiotic consumption may have a positive effect on psychological symptoms of depression, anxiety, and perceived stress in healthy human volunteers.”

 

Depression

 

Peripheral zinc and neopterin concentrations are associated with mood severity in bipolar disorder in a gender-specific manner. “Two peripheral markers of the acute phase immune response, zinc and neopterin, are consistently associated with severity of depression in literature. We found that zinc concentrations were significantly lower in the BD group at baseline, and there was also a significant interaction between gender and zinc, associated with depression severity. Also, we found a significant interaction between gender and neopterin, associated with mania severity. We found that mania severity was associated with neopterin in men, while depression severity was positively associated with zinc in women.”

The Relationship between Fatty Acids and Different Depression-Related Brain Regions, and Their Potential Role as Biomarkers of Response to Antidepressants. Full pdf. “Diet impacts various aspects of health, including depression. The fatty acid composition of the Western diet, which has a high ratio of n-6:n-3 polyunsaturated fatty acids, is associated with increased incidence of depression. The brain is rich in lipids, and dietary fatty acids act within specific brain regions to regulate processes that impact emotional behavior. This manuscript reviews existing evidence demonstrating brain region-specific fatty acid profiles, and posits that specific fatty acids may serve as predictive biomarkers of response to antidepressants. Furthermore, increasing blood levels of certain fats, such as n-3s, via dietary intervention may serve as an adjunct to improve the efficacy of antidepressants.”

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity. Full pdf. “Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity.”

Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: A randomized, double-blind, placebo-controlled trial.The aim of this study was to determine the effect of magnesium supplementation on the depression status of depressed patients suffering from magnesium deficiency. Daily consumption of 500 mg magnesium oxide tablets for ≥8 wk by depressed patients suffering from magnesium deficiency leads to improvements in depression status and magnesium levels. Therefore, assessment of the magnesium serum and resolving this deficiency positively influence the treatment of depressed patients.

Clinical Use of Curcumin in Depression: A Meta-Analysis.Six clinical trials with a total of 377 patients were reviewed, comparing the use of curcumin to placebo. In patients with depression, the pooled standardized mean difference from baseline Hamilton Rating Scale for Depression scores support the significant clinical efficacy of curcumin in ameliorating depressive symptoms. Significant anti-anxiety effects were also reported in 3 of the trials. Notably, no adverse events were reported in any of the trials.”

Adjunctive low-dose docosahexaenoic acid (DHA) for major depression: An open-label pilot trial.After 8 weeks, 54% of patients had a ≥50% reduction on the HAM-D, and 45% were in remission. No significant adverse reactions to DHA were found. Within the major limits of this open-label pilot study, the results suggest that DHA may provide additional adjunctive benefits in patients with mild- to -moderate depression.”

Dietary zinc and iron intake and risk of depression: A meta-analysis.The present meta-analysis indicates inverse associations between dietary zinc and iron intake and risk of depression.”

Vitamin D and mental health in children and adolescents.While vitamin D is known to be relevant for bone health, evidence has recently accumulated for an impact on mental health. Overall, results from 25 cross-sectional studies as well as from 8 longitudinal studies suggest a role of vitamin D in the pathogenesis of mental disorders in childhood and adolescence. Randomized controlled trials in childhood and adolescents are urgently needed to support the potential of vitamin D as a complementary therapeutic option in mental disorders.”

Curcumin for neuropsychiatric disorders: a review of in vitro, animal and human studies. Full pdf. “In this systematic review, in vitro, animal, and human studies investigating the potential of curcumin as a treatment for neuropsychiatric disorders such as major depressive disorder, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), bipolar disorder, psychotic disorders, and autism are reviewed, and directions for future research are proposed. It is concluded that curcumin is a promising, natural agent for many of these conditions, however, further research utilising robust, clinical designs are essential. The problem associated with the poor oral bioavailability of standard curcumin also requires consideration. Currently the greatest support for the efficacy of curcumin is for the treatment of major depressive disorder.”

Clinical use of nutraceuticals in the adjunctive treatment of depression in mood disorders. Our recent systematic reviews and meta-analyses of nutrient pharmacotherapies in the treatment unipolar depression revealed primarily positive results for replicated studies testing S-adenosyl methionine (SAMe), methylfolate, omega-3 (EPA or ethyl-EPA), and Vitamin D; with supportive isolated studies found for creatine and an amino acid combination. Mixed results were found for zinc, folic acid, Vitamin C, and tryptophan; and non-significant study results for inositol. In bipolar depression, omega-3 and N-acetyl cysteine (NAC) were found to have supportive evidence.”

Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application.A body of evidence has implicated dietary deficiency in omega-3 polyunsaturated fatty acids (n-3 PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in the pathophysiology and etiology of recurrent mood disorders including major depressive disorder (MDD) and bipolar disorder. Meta-analyses provide strong evidence that patients with mood disorders exhibit low blood n-3 PUFA levels which are associated with increased risk for the initial development of mood symptoms in response to inflammation. Collectively, these findings implicate dietary n-3 PUFA insufficiency, particularly during development, in the pathophysiology of mood dysregulation, and support implementation of routine screening for and treatment of n-3 PUFA deficiency in patients with mood disorders.”

Association of Mood Disorders with Serum Zinc Concentrations in Adolescent Female Students.The main objective of this study was to assess the correlation between serum zinc levels and mood disorders in high school female students. Each 10 μg/dL increment in serum zinc levels led to 0.3 and 0.01 decrease in depression and anxiety scores, respectively (p < 0.05). Serum zinc levels were inversely correlated with mood disorders including depression and anxiety in adolescent female students. Increasing serum levels of zinc in female students could improve their mood disorders.

Clinical use of Hypericum perforatum (St John’s wort) in depression: A meta-analysis.27 clinical trials with a total of 3808 patients were reviewed, comparing the use of St John’s wort and SSRI. In patients with depression, St John’s wort demonstrated comparable response and remission rate, and significantly lower discontinuation/dropout  rate compared to standard SSRIs.” Before considering the use of St John’s wort, it is important to ensure that you are actually using a high quality herbal product. Many herbal products on the market are of very poor quality. See Supplements Buyer Beware and Supplements – The Plot Thickens.

Current Clinical Applications of Ω-6 and Ω-3 Fatty Acids.Many psychiatric disorders, particularly schizophrenia and major depressive disorder (MDD), have shown positive results when supplementation has been used as an adjunct to standard pharmacotherapy.

Magnesium, C-reactive protein, and cortisol in drug-naïve patients with short illness-duration, first episode major depressive disorder: possible immunomodulatory role for magnesium.Plasma magnesium concentration alterations, hypercortisolaemia, and systemic inflammation are observed in major depressive disorder (MDD). This exploratory study examined whether, and to what extent, plasma magnesium is related to C-reactive protein (CRP) levels and cortisolaemia in MDD. The study supports the hypothesis linking hypercortisolaemia to systemic inflammation, with hypermagnesaemia exerting an immunomodulatory action at early stages of the disease.”

Polyunsaturated Fatty Acids and Suicide Risk in Mood Disorders: A Systematic Review. The reviewed studies suggest that subjects with psychiatric conditions have a depletion of omega-3 PUFAs compared to control groups. This fatty acid depletion has also been found to contribute to suicidal thoughts and behavior in some cases.”

Tryptophan Intake in the US Adult Population Is Not Related to Liver or Kidney Function but Is Associated with Depression and Sleep Outcomes.Tryptophan is an indispensable amino acid and is a precursor of the neurotransmitter serotonin. Tryptophan metabolites, such as serotonin and melatonin, are thought to participate in the regulation of mood and sleep and tryptophan is used to treat insomnia, sleep apnea, and depression. Tryptophan intake was inversely associated with self-reported level of depression and positively associated with sleep duration.”

Magnesium and depression.It [magnesium] plays a vital modulatory role in brain biochemistry, influencing several neurotransmission pathways associated with the development of depression. Personality changes, including apathy, depression, agitation, confusion, anxiety, and delirium are observed when there is a deficiency of this element. Since the extracellular concentration of magnesium ions may not reflect their intracellular level, none of the current methods of evaluating magnesium status is regarded as satisfactory. The mood-improving potential of magnesium compounds have been confirmed by the results of numerous pre-clinical and clinical studies. It seems that magnesium supplementation is well-tolerated and enhances the efficacy of conventional antidepressant treatments, and as such could be a valuable addition to the standard treatments for depression.”

The effect of methylated vitamin B complex on depressive and anxiety symptoms and quality of life in adults with depression. Full pdf. “The formula used in the current study was well tolerated among all subjects. The Max Stress B formula showed modest improvements in mood and mental health, making our findings consistent with the prior studies. Thus, our study shows that a high quality, whole-food dietary supplement may offer an opportunity for adults with depression to improve mood symptoms and quality of life.”

Manic switches induced by antidepressants: an umbrella review comparing randomized controlled trials and observational studies. A serious concern with patients on antidepressants, the possibility of them having a manic episode, especially if they have bipolar disorder. “Our results highlight an underestimation of the rates of manic switch under antidepressants in RCTs compared to the rates observed in observational studies.”

 

Anxiety

 

Cytokine Levels in Panic Disorder: Evidence for a Dose-Response Relationship.Several studies have investigated possible biological correlates of mental disorders. Although some studies have consistently reported elevated levels of serum inflammatory markers in depression, very few have evaluated cytokine levels in patients with lifetime panic disorder (PD). Significantly higher mean levels of serum IL-6  but not of tumor necrosis factor-α  or IL-10 , were associated with current PD compared to remitted PD. Our findings support a proinflammatory state in patients with current PD that is independent of possible confounders. 

Anticonvulsant, Anxiolytic, and Sedative Activities of Verbena officinalis. Full pdf. “These results indicate that Verbena officinalis possess anticonvulsant, anxiolytic and sedative activities, which provides scientific background for its medicinal application in various neurological ailments, such as epilepsy, anxiety, and insomnia.”

Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder.Subjects with moderate to severe GAD [general anxiety disorder] received open-label treatment with pharmaceutical-grade chamomile extract 1500mg/day for up to 8 weeks. Chamomile extract produced a clinically meaningful reduction in GAD symptoms over 8 weeks, with a response rate comparable to those observed during conventional anxiolytic drug therapy and a favorable adverse event profile.” Please note that pharmaceutical grade chamomile extract was used in this study. Many retail herbs and those available over the internet are of poor quality.

Ginkgo biloba as an alternative medicine in the treatment of anxiety in dementia and other psychiatric disorders.Various preclinical and clinical studies have shown a positive effect of Ginkgo biloba to improve cognitive abilities in impaired individuals and reducing anxiety under pathological conditions.”

The effects of magnesium supplementation on subjective anxiety.The efficacy of Mg in the treatment of anxiety in the mildly anxious and those reporting premenstrual syndrome-related anxiety is suggestive of a beneficial effect of Mg intake.”

The Effect of Aromatherapy on Anxiety in Patients.Rose water noticeably reduces the anxiety of hemodialysis patients. Therefore, inhalation of rose water can improve the patient’s emotional and spiritual condition during hemodialysis treatment.”

 

Schizophrenia

 

Relationship between Toxoplasma gondii Seropositivity and Acoustic Startle Response in an Inner-City Population.Toxoplasma gondii (TOXO) is a neuroinvasive protozoan parasite that induces the formation of persistent cysts in mammalian brains. It infects approximately 1.1 million people in the United States annually. Latent TOXO infection is implicated in the etiology of psychiatric disorders, especially schizophrenia (Scz), and has been correlated with modestly impaired cognition.”

Neurobehavioural evaluation of resveratrol in murine models of anxiety and schizophrenia.Administration of resveratrol at doses used in this study [200 and 400 mg/kg] produced anxiolysis and anti-psychotic effects in mice.”

The brain-gut axis dysfunctions and hypersensitivity to food antigens in the etiopathogenesis of schizophrenia. Full text. “This paper is a review of the literature on this subject which presents factors both involved in the functioning of brain-gut axis and important for the development of schizophrenia, i.e. 1. intestinal microbiome (intestinal microbiota), 2. permeable intestine (leaky gut syndrome), 3. hypersensitivity to food antigens, including gluten and casein of cow’s milk. Research results seem to be very promising and indicate the possibility of improved clinical outcomes in some patients with schizophrenia by modifying diet, use of probiotics, and the implementation of antibiotic therapy of specific treatment groups.”

Probiotic normalization of Candida albicans in schizophrenia: a randomized, placebo-controlled, longitudinal pilot study.Results from this pilot study hint at an association of C. albicans seropositivity with worse positive psychiatric symptoms, which was confirmed in a larger cohort of 384 males with schizophrenia.”

 

Role of the Immune System in Mood Disorders

 

Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression. Population-based studies have associated inflammation, particularly higher C-reactive protein (CRP), with depressive severity. Higher CRP levels were significantly associated with greater overall MADRS [Montgomery Aasberg Depression Rating Scale] symptom severity, which was significant among women but not among men. Among women, higher CRP was associated with increased severity on observed mood, cognitive symptoms, interest-activity, and suicidality, but we found no significant associations among men.”

Association between depression and enterovirus infection: A nationwide population-based cohort study.Enterovirus (EV) infection is common among children and adolescents. Few studies have investigated the relationship of depression after EV infection. This study explores an association between EV infection and subsequent depression in children and adolescents and assesses the risk of depression after EV infection with central nervous system involvement in a nationwide population-based retrospective cohort. CNS EV infection was associated with increased risk of depression. The results suggested that children and adolescents with CNS EV infection were a susceptible group for subsequent depressive disorders.”

Hepatitis C virus infection, and neurological and psychiatric disorders – A review.An association between hepatitis C virus infection and neuropsychiatric symptoms has been proposed for some years. A variety of studies have been undertaken to assess the nature and severity of these symptoms, which range from fatigue and depression to defects in attention and verbal reasoning. There is evidence of mild neurocognitive impairment in some patients with HCV infection, which is not fully attributable to liver dysfunction or psychosocial factors. Further evidence of a biological cerebral effect has arisen from studies using magnetic resonance spectroscopy; metabolic abnormalities correlate with cognitive dysfunction and resemble the patterns of neuroinflammation that have been described in HIV infection. Importantly, patient reported outcomes improve following successful antiviral therapy.”

The effects of vitamin B on the immune/cytokine network and their involvement in depression.Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression.

Improvement of psychiatric symptoms in youth following resolution of sinusitis. Accumulating evidence supports a role for inflammation in psychiatric illness, and the onset or exacerbation of psychiatric symptoms may follow non-CNS infections. 10/150 (6.6%) patients had isolated sinusitis at the time of their neuropsychiatric deterioration. Eight patients received antibiotics to treat sinusitis, three of whom also received sinus surgery. Neuropsychiatric symptoms improved in all eight patients concurrent with resolution of sinusitis per parent report and clinician assessment. Improvement of psychiatric symptoms correlated with resolution of sinus disease in this retrospective study. Identification, treatment, and resolution of underlying infections, including sinusitis, may have the potential to change the trajectory of some neuropsychiatric illnesses.”

 

Environmental Factors in Mood Disorders

 

Adverse effects of maternal exposure to bisphenol F on the anxiety- and depression-like behavior of offspring.Bisphenol F (BPF) exposure altered offspring behavior significantly, resulting in increases in anxiety and depressive state. The influence of BPF was stronger than that of bisphenol A (BPA). We demonstrated novel evidence that BPF influences the behavior of offspring.”

 

WARNING
Please seek professional advice when selecting supplements. Self-prescribing is not recommended and supplements should not be taken in conjunction with current medication without proper supervision.